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Specialized regulatory T cells control venous blood clot resolution through SPARC
- Source :
- Blood; March 2021, Vol. 137 Issue: 11 p1517-1526, 10p
- Publication Year :
- 2021
-
Abstract
- The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg population that forms the matricellular acid– and cysteine-rich protein SPARC (secreted protein acidic and rich in cysteine) and show that SPARC enhances monocyte MMP activity and that SPARC+ Tregs are crucial for blood clot resorption. By comparing different treatment times, we define a therapeutic window of Treg expansion that accelerates clot resorption.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 137
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs55585633
- Full Text :
- https://doi.org/10.1182/blood.2020005407