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Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies
- Source :
- Cell Reports; March 2021, Vol. 34 Issue: 11
- Publication Year :
- 2021
-
Abstract
- As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (±2) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitroinfectivity. We demonstrated that the frequencies of SARS-CoV-2-specific CD4+CD40L+T cells and Spike-specific B cells were associated with the anti-SARS-CoV-2 antibodies and the magnitude of neutralizing activity. The plasma proteome confirmed the association between cellular and humoral SARS-CoV-2 immunity, and PRNT+patients show higher viral signal transduction molecules (SLAMF1, CD244, CLEC4G). This work sheds lights on cellular and humoral anti-SARS-CoV-2 responses in children, which may drive future vaccination trial endpoints and quarantine measures policies.
Details
- Language :
- English
- ISSN :
- 22111247
- Volume :
- 34
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Cell Reports
- Publication Type :
- Periodical
- Accession number :
- ejs55559954
- Full Text :
- https://doi.org/10.1016/j.celrep.2021.108852