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Anti-tumor effect of carrimycin on oral squamous cell carcinoma cells in vitroand in vivo
- Source :
- Translational Oncology; June 2021, Vol. 14 Issue: 6
- Publication Year :
- 2021
-
Abstract
- •Our study is the first to explore and report the anti-tumor effect of carrimycin.•Carrimycin inhibits the proliferation, colony formation and migration ability of oral squamous cell carcinoma cells in vitro, as well as arrests cell cycle in G0/G1 and promotes cell apoptosis.•Carrimycin suppresses OSCC tumor growth in xenograft model.•Carrimycin regulates the PI3K/AKT and MAPK pathways.
Details
- Language :
- English
- ISSN :
- 19447124 and 19365233
- Volume :
- 14
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Translational Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs55541421
- Full Text :
- https://doi.org/10.1016/j.tranon.2021.101074