Back to Search
Start Over
Adverse cardiovascular magnetic resonance phenotypes are associated with greater likelihood of incident coronavirus disease 2019: findings from the UK Biobank
- Source :
- Aging: Clinical and Experimental Research; April 2021, Vol. 33 Issue: 4 p1133-1144, 12p
- Publication Year :
- 2021
-
Abstract
- Background: Coronavirus disease 2019 (COVID-19) disproportionately affects older people. Observational studies suggest indolent cardiovascular involvement after recovery from acute COVID-19. However, these findings may reflect pre-existing cardiac phenotypes. Aims: We tested the association of baseline cardiovascular magnetic resonance (CMR) phenotypes with incident COVID-19. Methods: We studied UK Biobank participants with CMR imaging and COVID-19 testing. We considered left and right ventricular (LV, RV) volumes, ejection fractions, and stroke volumes, LV mass, LV strain, native T1, aortic distensibility, and arterial stiffness index. COVID-19 test results were obtained from Public Health England. Co-morbidities were ascertained from self-report and hospital episode statistics (HES). Critical care admission and death were from HES and death register records. We investigated the association of each cardiovascular measure with COVID-19 test result in multivariable logistic regression models adjusting for age, sex, ethnicity, deprivation, body mass index, smoking, diabetes, hypertension, high cholesterol, and prior myocardial infarction. Results: We studied 310 participants (n= 70 positive). Median age was 63.8 [57.5, 72.1] years; 51.0% (n= 158) were male. 78.7% (n= 244) were tested in hospital, 3.5% (n= 11) required critical care admission, and 6.1% (n= 19) died. In fully adjusted models, smaller LV/RV end-diastolic volumes, smaller LV stroke volume, and poorer global longitudinal strain were associated with significantly higher odds of COVID-19 positivity. Discussion: We demonstrate association of pre-existing adverse CMR phenotypes with greater odds of COVID-19 positivity independent of classical cardiovascular risk factors. Conclusions: Observational reports of cardiovascular involvement after COVID-19 may, at least partly, reflect pre-existing cardiac status rather than COVID-19 induced alterations.
Details
- Language :
- English
- ISSN :
- 15940667 and 17208319
- Volume :
- 33
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Aging: Clinical and Experimental Research
- Publication Type :
- Periodical
- Accession number :
- ejs55511305
- Full Text :
- https://doi.org/10.1007/s40520-021-01808-z