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Protective effects of acute exercise preconditioning on disuse-induced muscular atrophy in aged muscle: a narrative literature review
- Source :
- The Journal of Physiological Sciences; December 2020, Vol. 70 Issue: 1
- Publication Year :
- 2020
-
Abstract
- Aging is associated with a progressive loss of skeletal muscle mass and strength, resulting in frailty and lower quality of life in older individuals. At present, a standard of clinical or pharmacological care to prevent the adverse effects of aging does not exist. Determining the mechanism(s) responsible for muscular atrophy in disused aged muscle is a required key step for the development of effective countermeasures. Studies suggest an age-related differential response of genes and signalings to muscle disuse in both rodents and humans, implying the possibility that effective countermeasures to prevent disuse muscle atrophy may be age-specific. Notably, exercise preconditioning can attenuate disuse-induced muscular atrophy in rodent and human skeletal muscles; however, information on age-specific mechanisms of this exercise-induced protection remains limited. This mini-review aimed to summarize the protective effects of acute exercise preconditioning on muscular atrophy in aged muscle and provide potential mechanisms for its preventive effect on skeletal muscle wasting.
Details
- Language :
- English
- ISSN :
- 18806546 and 18806562
- Volume :
- 70
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- The Journal of Physiological Sciences
- Publication Type :
- Periodical
- Accession number :
- ejs55400230
- Full Text :
- https://doi.org/10.1186/s12576-020-00783-w