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Safety and immunogenicity of two novel type 2 oral poliovirus vaccine candidates compared with a monovalent type 2 oral poliovirus vaccine in healthy adults: two clinical trials

Authors :
De Coster, Ilse
Leroux-Roels, Isabel
Bandyopadhyay, Ananda S
Gast, Christopher
Withanage, Kanchanamala
Steenackers, Katie
De Smedt, Philippe
Aerssens, Annelies
Leroux-Roels, Geert
Oberste, M Steven
Konopka-Anstadt, Jennifer L
Weldon, William C
Fix, Alan
Konz, John
Wahid, Rahnuma
Modlin, John
Clemens, Ralf
Costa Clemens, Sue Ann
Bachtiar, Novilia S
Van Damme, Pierre
Source :
The Lancet; January 2021, Vol. 397 Issue: 10268 p39-50, 12p
Publication Year :
2021

Abstract

Two novel type 2 oral poliovirus vaccine (OPV2) candidates, novel OPV2-c1 and novel OPV2-c2, designed to be more genetically stable than the licensed Sabin monovalent OPV2, have been developed to respond to ongoing polio outbreaks due to circulating vaccine-derived type 2 polioviruses.

Details

Language :
English
ISSN :
01406736 and 1474547X
Volume :
397
Issue :
10268
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs54819237
Full Text :
https://doi.org/10.1016/S0140-6736(20)32541-1