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Costameric integrin and sarcoglycan protein levels are altered in a Drosophilamodel for Limb-girdle muscular dystrophy type 2H

Authors :
Bawa, Simranjot
Gameros, Samantha
Baumann, Kenny
Brooks, David S.
Kollhoff, Joseph A.
Zolkiewski, Michal
Re Cecconi, Andrea David
Panini, Nicolò
Russo, Massimo
Piccirillo, Rosanna
Johnson, David K.
Kashipathy, Maithri M.
Battaile, Kevin P.
Lovell, Scott
Bouyain, Samuel E.A.
Kawakami, Jessica
Geisbrecht, Erika R.
Source :
Molecular Biology of the Cell; February 2021, Vol. 32 Issue: 3 p260-273, 14p
Publication Year :
2021

Abstract

Expression of human disease-causing LGMD2H alleles in Drosophilacauses muscle degeneration and elevated levels of integrin and sarcoglycan costamere proteins, likely exacerbating disease progression.

Details

Language :
English
ISSN :
10591524 and 19394586
Volume :
32
Issue :
3
Database :
Supplemental Index
Journal :
Molecular Biology of the Cell
Publication Type :
Periodical
Accession number :
ejs54808760
Full Text :
https://doi.org/10.1091/mbc.E20-07-0453