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Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients

Authors :
Wang, Haiyang
Feng, Chao
Lu, Meixin
Zhang, Biao
Xu, Yingchen
Zeng, Quan
Xi, Jiafei
Zhou, Junnian
Ying, Xiaomin
Zhang, Jian
Yue, Wen
Pei, Xuetao
Source :
Translational Oncology; January 2021, Vol. 14 Issue: 1
Publication Year :
2021

Abstract

•Integrative single-cell transcriptome analysis reveals the accumulation of fibroblasts in liver cancer tissues.•SPARCL1expression distinguishes two subpopulations of the liver cancer-distinct fibroblasts.•SPARCL1positive fibroblasts are related to favorable prognosis of liver cancer patients.

Details

Language :
English
ISSN :
19447124 and 19365233
Volume :
14
Issue :
1
Database :
Supplemental Index
Journal :
Translational Oncology
Publication Type :
Periodical
Accession number :
ejs54754114
Full Text :
https://doi.org/10.1016/j.tranon.2020.100981