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Zelkovamycins B–E, Cyclic Octapeptides Containing Rare Amino Acid Residues from an Endophytic Kitasatosporasp
- Source :
- Organic Letters; December 2020, Vol. 22 Issue: 23 p9346-9350, 5p
- Publication Year :
- 2020
-
Abstract
- Four unusual cyclopeptides, zelkovamycins B–E (1–4), were isolated from an endophytic Kitasatosporasp. Zelkovamycin B was featured by an unprecedented 3-methyl-5-hydroxypyrrolidine-2,4-dione ring system linked to the cyclopeptide skeleton. Their structures and full configurations were established by spectroscopic analysis, Marfey’s method, and NMR calculations. A plausible biosynthetic pathway for zelkovamycins was proposed based on gene cluster analysis. Zelkovamycin E displayed potent inhibitory activity against H1N1 influenza A virus.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 22
- Issue :
- 23
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs54676906
- Full Text :
- https://doi.org/10.1021/acs.orglett.0c03565