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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
Authors :
Ramasamy, Maheshi N Minassian, Angela M Ewer, Katie J Flaxman, Amy L Folegatti, Pedro M Owens, Daniel R Voysey, Merryn Aley, Parvinder K Angus, Brian Babbage, Gavin Belij-Rammerstorfer, Sandra Berry, Lisa Bibi, Sagida Bittaye, Mustapha Cathie, Katrina Chappell, Harry Charlton, Sue Cicconi, Paola Clutterbuck, Elizabeth A Colin-Jones, Rachel Dold, Christina Emary, Katherine R W Fedosyuk, Sofiya Fuskova, Michelle Gbesemete, Diane Green, Catherine Hallis, Bassam Hou, Mimi M Jenkin, Daniel Joe, Carina C D Kelly, Elizabeth J Kerridge, Simon Lawrie, Alison M Lelliott, Alice Lwin, May N Makinson, Rebecca Marchevsky, Natalie G Mujadidi, Yama Munro, Alasdair P S Pacurar, Mihaela Plested, Emma Rand, Jade Rawlinson, Thomas Rhead, Sarah Robinson, Hannah Ritchie, Adam J Ross-Russell, Amy L Saich, Stephen Singh, Nisha Smith, Catherine C Snape, Matthew D Song, Rinn Tarrant, Richard Themistocleous, Yrene Thomas, Kelly M Villafana, Tonya L Warren, Sarah C Watson, Marion E E Douglas, Alexander D Hill, Adrian V S Lambe, Teresa Gilbert, Sarah C Faust, Saul N Pollard, Andrew J Aboagye, Jeremy Adams, Kelly Ali, Aabidah Allen, Elizabeth R. Allen, Lauren Allison, Jennifer L. Andritsou, Foteini Anslow, Rachel Arbe-Barnes, Edward H. Baker, Megan Baker, Natalie Baker, Philip Baleanu, Ioana Barker, Debbie Barnes, Eleanor Barrett, Jordan R. Barrett, Kelly Bates, Louise Batten, Alexander Beadon, Kirsten Beckley, Rebecca Bellamy, Duncan Berg, Adam Bermejo, Laura Berrie, Eleanor Beveridge, Amy Bewley, Kevin Bijker, Else M. Birch, Geeta Blackwell, Luke Bletchly, Heather Blundell, Caitlin L. Blundell, Susannah R. Bolam, Emma Boland, Elena Bormans, Daan Borthwick, Nicola Boukas, Konstantinos Bower, Thomas Bowring, Francesca Boyd, Amy Brenner, Tanja Brown, Phillip Brown-O'Sullivan, Charlie Bruce, Scott Brunt, Emily Burbage, Jamie Burgoyne, Joshua Buttigieg, Karen R. Byard, Nicholas Cabera Puig, Ingrid Camara, Susana Cao, Michelangelo Cappuccini, Federica Carr, Melanie Carroll, Miles W. Cashen, Paul Cavey, Ana Chadwick, Jim Challis, Ruth Chapman, David Charles, David Chelysheva, Irina Cho, Jee-Sun Cifuentes, Liliana Clark, Elizabeth Collins, Sarah Conlon, Christopher P. Coombes, Naomi S. Cooper, Rachel Cooper, Cushla Crocker, Wendy E.M. Crosbie, Sarah Cullen, Dan Cunningham, Christina Cuthbertson, Fiona Datoo, Brad E. Dando, Lynne Datoo, Mehreen S. Datta, Chandrabali Davies, Hannah Davies, Sarah Davis, Elizabeth J. Davis, Judith Dearlove, David Demissie, Tesfaye Di Marco, Stefania Di Maso, Claudio DiTirro, Danielle Docksey, Claire Dong, Tao Donnellan, Francesca R. Douglas, Naomi Downing, Charlotte Drake, Jonathan Drake-Brockman, Rachael Drury, Ruth E. Dunachie, Susanna J. Edwards, Christopher J. Edwards, Nick J. El Muhanna, Omar Elias, Sean C. Elliott, Ryan S. Elmore, Michael J. English, Marcus Rex Felle, Sally Feng, Shuo Ferreira Da Silva, Carla Field, Samantha Fisher, Richard Fixmer, Carine Ford, Karen J. Fowler, Jamie Francis, Emma Frater, John Furze, Julie Galian-Rubio, Pablo Galloway, Celine Garlant, Harriet Gavrila, Madita Gibbons, Felicity Gibbons, Karyna Gilbride, Ciaran Gill, Hardeep Godwin, Kerry Gordon-Quayle, Katherine Gorini, Giacomo Goulston, Lyndsey Grabau, Caroline Gracie, Lara Graham, Nichola Greenwood, Nicola Griffiths, Oliver Gupta, Gaurav Hamilton, Elizabeth Hanumunthadu, Brama Harris, Stephanie A. Harris, Tara Harrison, Daisy Hart, Thomas C. Hartnell, Birgit Haskell, Louise Hawkins, Sophia Henry, John Aaron Hermosin Herrera, Macarena Hill, David Hill, Jennifer Hodges, Gina Hodgson, Susanne H.C. Horton, Katie L. Howe, Elizabeth Howell, Nicola Howes, Jessica Huang, Ben Humphreys, Jonathan Humphries, Holly E. Iveson, Poppy Jackson, Frederic Jackson, Susan Jauregui, Sam Jeffers, Helen Jones, Bryony Jones, Christine E. Jones, Elizabeth Jones, Kathryn Joshi, Amar Kailath, Reshma Keen, Jade Kelly, Dearbhla M. Kelly, Sarah Kelly, Debbie Kerr, David Khan, Liaquat Khozoee, Baktash Killen, Annabel Kinch, Jasmin King, Lloyd D.W. King, Thomas B. Kingham, Lucy Klenerman, Paul Knight, Julian C. Knott, Daniel Koleva, Stanislava Lang, Gail Larkworthy, Colin W. Larwood, Jessica P.J. Law, Rebecca Lee, Arlene Lee, Kim Y.N. Lees, Emily A. Leung, Stephanie Li, Yuanyuan Lias, Amelia M. Linder, Aline Lipworth, Samuel Liu, Shuchang Liu, Xinxue Lloyd, Stephanie Loew, Lisa Lopez Ramon, Raquel Madhavan, Meera Mainwaring, David O. Mallett, Garry Mansatta, Kushal Marinou, Spyridoula Marius, Phedra Marlow, Emma Marriott, Paula Marshall, Julia L. Martin, Jane Masters, Shauna McEwan, Joanne McGlashan, Joanna L. McInroy, Lorna McRobert, Nicky Megson, Clare Mentzer, Alexander J. Mirtorabi, Neginsadat Mitton, Celia Moore, Maria Moran, Marni Morey, Ella Morgans, Róisín Morris, Susan J. Morrison, Hazel Morrison Morshead, Gertraud Morter, Richard Moya, Nathifa A. Mukhopadhyay, Ekta Muller, Jilly Munro, Claire Murphy, Sarah Mweu, Philomena Noé, Andrés Nugent, Fay L. O'Brien, Katie O'Connor, Daniel Oguti, Blanché Olchawski, Victoria Oliveira, Catarina O'Reilly, Peter John Osborne, Piper Owen, Lydia Owino, Nelly Papageorgiou, Panagiotis Parracho, Helena Parsons, Karen Patel, Bhumika Patrick-Smith, Maia Peng, Yanchun Penn, Elizabeth J. Peralta-Alvarez, Marco Polo Perring, James Petropoulos, Christos Phillips, Daniel J. Pipini, Dimitra Pollard, Samuel Poulton, Ian Pratt, Danny Presland, Laura Proud, Pamela C. Provstgaard-Morys, Samuel Pueschel, Sophie Pulido, David Rabara, Ria Radia, Kajal Rajapaska, Durga Ramos Lopez, Fernando Ratcliffe, Helen Rayhan, Sara Rees, Byron Reyes Pabon, Emilia Roberts, Hannah Robertson, Isla Roche, Sophie Rollier, Christine S. Romani, Rossana Rose, Zoe Rudiansyah, Indra Sabheha, Sabeha Salvador, Stephannie Sanders, Helen Sanders, Katherine Satti, Iman Sayce, Chloe Schmid, Annina B. Schofield, Ella Screaton, Gavin Sedik, Cynthia Seddiqi, Samiullah Segireddy, Rameswara R. Selby, Beatrice Shaik, Imam Sharpe, Hannah R. Shaw, Robert Shea, Adam Silk, Sarah Silva-Reyes, Laura Skelly, Donal T. Smith, David J. Smith, Daniel C. Smith, Nicholas Spencer, Alexandra J. Spoors, Louise Stafford, Elizabeth Stamford, Imogen Stockdale, Lisa Stockley, David Stockwell, Lisa V. Stokes, Matthew Strickland, Louise H. Stuart, Arabella Sulaiman, Sulaiman Summerton, Eloise Swash, Zoe Szigeti, Anna Tahiri-Alaoui, Abdessamad Tanner, Rachel Taylor, Iona Taylor, Keja Taylor, Ursula te Water Naude, Rebecca Themistocleous, Andreas Thomas, Merin Thomas, Tonia M. Thompson, Amber Thompson, Kevin Thornton-Jones, Viv Tinh, Lan Tomic, Adriana Tonks, Susan Towner, James Tran, Nguyen Tree, Julian A. Truby, Adam Turner, Cheryl Turner, Richard Ulaszewska, Marta Varughese, Rachel Verbart, Dennis Verheul, Marije K. Vichos, Iason Walker, Laura Wand, Matthew E. Watkins, Bridget Welch, Jessica West, Alison J. White, Caroline White, Rachel Williams, Paul Woodyer, Mark Worth, Andrew T. Wright, Daniel Wrin, Terri Yao, Xin Li Zbarcea, Diana-Andreea Zizi, Dalila
Source :
The Lancet; December-January 2020, Vol. 396 Issue: 10267 p1979-1993, 15p
Publication Year :
2020
Abstract
Older adults (aged ≥70 years) are at increased risk of severe disease and death if they develop COVID-19 and are therefore a priority for immunisation should an efficacious vaccine be developed. Immunogenicity of vaccines is often worse in older adults as a result of immunosenescence. We have reported the immunogenicity of a novel chimpanzee adenovirus-vectored vaccine, ChAdOx1 nCoV-19 (AZD1222), in young adults, and now describe the safety and immunogenicity of this vaccine in a wider range of participants, including adults aged 70 years and older.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
396
Issue :
10267
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs54657487
Full Text :
https://doi.org/10.1016/S0140-6736(20)32466-1