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iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy

Authors :
Cichocki, Frank
Bjordahl, Ryan
Gaidarova, Svetlana
Mahmood, Sajid
Abujarour, Ramzey
Wang, Hongbo
Tuininga, Katie
Felices, Martin
Davis, Zachary B.
Bendzick, Laura
Clarke, Raedun
Stokely, Laurel
Rogers, Paul
Ge, Moyar
Robinson, Megan
Rezner, Betsy
Robbins, David L.
Lee, Tom T.
Kaufman, Dan S.
Blazar, Bruce R.
Valamehr, Bahram
Miller, Jeffrey S.
Source :
Science Translational Medicine; November 2020, Vol. 12 Issue: 568
Publication Year :
2020

Abstract

Natural killer cells derived from iPSCs prime T cells for anti–PD-1 immune checkpoint therapy.

Details

Language :
English
ISSN :
19466234 and 19466242
Volume :
12
Issue :
568
Database :
Supplemental Index
Journal :
Science Translational Medicine
Publication Type :
Periodical
Accession number :
ejs54573886
Full Text :
https://doi.org/10.1126/scitranslmed.aaz5618