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Natural Polymorphisms in Mycobacterium tuberculosisConferring Resistance to Delamanid in Drug-Naive Patients
- Source :
- Antimicrobial Agents and Chemotherapy; August 2020, Vol. 64 Issue: 11
- Publication Year :
- 2020
-
Abstract
- Mutations in the genes of the F420signaling pathway of Mycobacterium tuberculosiscomplex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosisstrains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 64
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs54451603
- Full Text :
- https://doi.org/10.1128/AAC.00513-20