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Effect of pimavanserin on anxious depression in patients with major depression and an inadequate response to previous therapy: secondary analysis of the clarity study
- Source :
- International Clinical Psychopharmacology; November 2020, Vol. 35 Issue: 6 p313-321, 9p
- Publication Year :
- 2020
-
Abstract
- In a post hoc analysis, the effect of pimavanserin on anxious depression was determined from CLARITY, a randomized, double-blind, placebo-controlled study in patients with major depression and an inadequate response to previous therapy. Patients were randomized in a 3:1 ratio to placebo or pimavanserin 34 mg daily added to ongoing antidepressant therapy. At 5 weeks, placebo nonresponders were rerandomized to placebo or pimavanserin for an additional 5 weeks. Mean change from baseline to week 5 for the Hamilton depression rating scale (HAMD) anxiety/somatization (AS) factor was examined for all patients and those with a score ≥7 at baseline. Least squares (LS) mean [standard error (SE)] difference between placebo and pimavanserin for the AS factor score was −1.5 (0.41) [95% confidence interval (CI) −2.4 to −0.7; P= 0.0003; effect size: 0.634]. Among patients with an AS factor score ≥7 at baseline, LS mean (SE) difference was −2.2 (0.66) (95% CI −3.5 to −0.9; P= 0.0013; effect size: 0.781). Response rates (≥50% reduction in HAMD-17 from baseline) were 22.4 and 55.2% (P= 0.0012) and remission rates (HAMD-17 total score <7) were 5.3 and 24.1% (P= 0.0047), respectively, with placebo and pimavanserin among patients with a baseline AS factor score ≥7. Among patients with anxious major depressive disorder at baseline, adjunctive pimavanserin was associated with a significant improvement.
Details
- Language :
- English
- ISSN :
- 02681315 and 14735857
- Volume :
- 35
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- International Clinical Psychopharmacology
- Publication Type :
- Periodical
- Accession number :
- ejs54352113
- Full Text :
- https://doi.org/10.1097/YIC.0000000000000328