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β-actin contributes to open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprograming
- Source :
- Molecular Biology of the Cell; November 2020, Vol. 31 Issue: 23 p2511-2521, 11p
- Publication Year :
- 2020
-
Abstract
- We demonstrate that nuclear actin regulates heterochromatin during adipogenesis by mediating Brg1 deposition at specific adipogenic gene loci to ensure binding of the transcription factor CEBPB. This mechanism contributes to CEBPA gene expression during adipogenic transcriptional reprograming.
Details
- Language :
- English
- ISSN :
- 10591524 and 19394586
- Volume :
- 31
- Issue :
- 23
- Database :
- Supplemental Index
- Journal :
- Molecular Biology of the Cell
- Publication Type :
- Periodical
- Accession number :
- ejs54138044
- Full Text :
- https://doi.org/10.1091/mbc.E19-11-0628