Clinical and Genomic Epidemiology of Carbapenem-Nonsusceptible Citrobacterspp. at a Tertiary Health Care Center over 2 Decades

Carbapenem-nonsusceptible Citrobacterspp. (CNSC) are increasingly recognized as health care-associated pathogens. Information regarding their clinical epidemiology, genetic diversity, and mechanisms of carbapenem resistance is lacking. We examined microbiology records of adult patients at the University of Pittsburgh Medical Center (UMPC) Presbyterian Hospital (PUH) from 2000 to 2018 for CNSC, as defined by ertapenem nonsusceptibility. Over this time frame, the proportion of CNSC increased from 4% to 10% (P?=?0.