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Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial

Authors :
Kessoku, Takaomi
Imajo, Kento
Kobayashi, Takashi
Ozaki, Anna
Iwaki, Michihiro
Honda, Yasushi
Kato, Takayuki
Ogawa, Yuji
Tomeno, Wataru
Kato, Shingo
Higurashi, Takuma
Yoneda, Masato
Kirikoshi, Hiroyuki
Kubota, Kazumi
Taguri, Masataka
Yamanaka, Takeharu
Usuda, Haruki
Wada, Koichiro
Kobayashi, Noritoshi
Saito, Satoru
Nakajima, Atsushi
Source :
The Lancet Gastroenterology & Hepatology; November 2020, Vol. 5 Issue: 11 p996-1007, 12p
Publication Year :
2020

Abstract

The laxative drug lubiprostone improves intestinal permeability in healthy volunteers. We aimed to assess efficacy and safety of lubiprostone in patients with non-alcoholic fatty liver disease (NAFLD) with constipation via attenuation of intestinal permeability.

Details

Language :
English
ISSN :
24681253
Volume :
5
Issue :
11
Database :
Supplemental Index
Journal :
The Lancet Gastroenterology & Hepatology
Publication Type :
Periodical
Accession number :
ejs53997349
Full Text :
https://doi.org/10.1016/S2468-1253(20)30216-8