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Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors
- Source :
- Journal of Investigative Dermatology; August 2020, Vol. 140 Issue: 8 p1501-1503, 3p
- Publication Year :
- 2020
-
Abstract
- Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al.(2020) have addressed some of these methodological issues.
Details
- Language :
- English
- ISSN :
- 0022202X and 15231747
- Volume :
- 140
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Journal of Investigative Dermatology
- Publication Type :
- Periodical
- Accession number :
- ejs53900651
- Full Text :
- https://doi.org/10.1016/j.jid.2020.02.017