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Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
Authors :
Folegatti, Pedro M Ewer, Katie J Aley, Parvinder K Angus, Brian Becker, Stephan Belij-Rammerstorfer, Sandra Bellamy, Duncan Bibi, Sagida Bittaye, Mustapha Clutterbuck, Elizabeth A Dold, Christina Faust, Saul N Finn, Adam Flaxman, Amy L Hallis, Bassam Heath, Paul Jenkin, Daniel Lazarus, Rajeka Makinson, Rebecca Minassian, Angela M Pollock, Katrina M Ramasamy, Maheshi Robinson, Hannah Snape, Matthew Tarrant, Richard Voysey, Merryn Green, Catherine Douglas, Alexander D Hill, Adrian V S Lambe, Teresa Gilbert, Sarah C Pollard, Andrew J Aboagye, Jeremy Adams, Kelly Ali, Aabidah Allen, Elizabeth Allison, Jennifer L. Anslow, Rachel Arbe-Barnes, Edward H. Babbage, Gavin Baillie, Kenneth Baker, Megan Baker, Natalie Baker, Philip Baleanu, Ioana Ballaminut, Juliana Barnes, Eleanor Barrett, Jordan Bates, Louise Batten, Alexander Beadon, Kirsten Beckley, Rebecca Berrie, Eleanor Berry, Lisa Beveridge, Amy Bewley, Kevin R. Bijker, Else Margreet Bingham, Tracey Blackwell, Luke Blundell, Caitlin L. Bolam, Emma Boland, Elena Borthwick, Nicola Bower, Thomas Boyd, Amy Brenner, Tanja Bright, Philip D. Brown-O'Sullivan, Charlie Brunt, Emily Burbage, Jamie Burge, Sharon Buttigieg, Karen R. Byard, Nicholas Cabera Puig, Ingrid Calvert, Anna Camara, Susana Cao, Michelangelo Cappuccini, Federica Carr, Melanie Carroll, Miles W. Carter, Victoria Cathie, Katrina Challis, Ruth J. Charlton, Sue Chelysheva, Irina Cho, Jee-Sun Cicconi, Paola Cifuentes, Liliana Clark, Helen Clark, Elizabeth Cole, Tom Colin-Jones, Rachel Conlon, Christopher P. Cook, Aislinn Coombes, Naomi S. Cooper, Rachel Cosgrove, Catherine A. Coy, Karen Crocker, Wendy E.M. Cunningham, Christina J. Damratoski, Brad E. Dando, Lynne Datoo, Mehreen S. Davies, Hannah De Graaf, Hans Demissie, Tesfaye Di Maso, Claudio Dietrich, Isabelle Dong, Tao Donnellan, Francesca R. Douglas, Naomi Downing, Charlotte Drake, Jonathan Drake-Brockman, Rachael Drury, Ruth Elizabeth Dunachie, Susanna Jane Edwards, Nick J. Edwards, Frances D.L. Edwards, Chris J. Elias, Sean C. Elmore, Michael J. Emary, Katherine R.W. English, Marcus Rex Fagerbrink, Susanne Felle, Sally Feng, Shuo Field, Samantha Fixmer, Carine Fletcher, Clare Ford, Karen J. Fowler, Jamie Fox, Polly Francis, Emma Frater, John Furze, Julie Fuskova, Michelle Galiza, Eva Gbesemete, Diane Gilbride, Ciaran Godwin, Kerry Gorini, Giacomo Goulston, Lyndsey Grabau, Caroline Gracie, Lara Gray, Zoe Guthrie, Lucy Belle Hackett, Mark Halwe, Sandro Hamilton, Elizabeth Hamlyn, Joseph Hanumunthadu, Brama Harding, Irasha Harris, Stephanie A. Harris, Andrew Harrison, Daisy Harrison, Clare Hart, Thomas C. Haskell, Louise Hawkins, Sophia Head, Ian Henry, John Aaron Hill, Jennifer Hodgson, Susanne H.C. Hou, Mimi M. Howe, Elizabeth Howell, Nicola Hutlin, Cecilia Ikram, Sabina Isitt, Catherine Iveson, Poppy Jackson, Susan Jackson, Frederic James, Sir William Jenkins, Megan Jones, Elizabeth Jones, Kathryn Jones, Christine E. Jones, Bryony Kailath, Reshma Karampatsas, Konstantinos Keen, Jade Kelly, Sarah Kelly, Dearbhla Kerr, David Kerridge, Simon Khan, Liaquat Khan, Uzma Killen, Annabel Kinch, Jasmin King, Thomas B. King, Lloyd King, Jade Kingham-Page, Lucy Klenerman, Paul Knapper, Francesca Knight, Julian C. Knott, Daniel Koleva, Stanislava Kupke, Alexandra Larkworthy, Colin W. Larwood, Jessica P.J. Laskey, Anna Lawrie, Alison M. Lee, Arlene Ngan Lee, Kim Yee Lees, Emily A Legge, Helen Lelliott, Alice Lemm, Nana-Marie Lias, Amelia M. Linder, Aline Lipworth, Samuel Liu, Xinxue Liu, Shuchang Lopez Ramon, Raquel Lwin, May Mabesa, Francesca Madhavan, Meera Mallett, Garry Mansatta, Kushal Marcal, Ines Marinou, Spyridoula Marlow, Emma Marshall, Julia L. Martin, Jane McEwan, Joanne McInroy, Lorna Meddaugh, Gretchen Mentzer, Alexander J. Mirtorabi, Neginsadat Moore, Maria Moran, Edward Morey, Ella Morgan, Victoria Morris, Susan Jane Morrison, Hazel Morshead, Gertraud Morter, Richard Mujadidi, Yama F. Muller, Jilly Munera-Huertas, Tatiana Munro, Claire Munro, Alasdair Murphy, Sarah Munster, Vincent J. Mweu, Philomena Noé, Andrés Nugent, Fay L. Nuthall, Elizabeth O'Brien, Katie O'Connor, Daniel Oguti, Blanché Oliver, Jennifer L. Oliveira, Catarina O'Reilly, Peter John Osborn, Mairead Osborne, Piper Owen, Cathy Owens, Daniel Owino, Nelly Pacurar, Mihaela Parker, Kaye Parracho, Helena Patrick-Smith, Maia Payne, Victoria Pearce, Jennifer Peng, Yanchun Peralta Alvarez, Marco Polo Perring, James Pfafferott, Katja Pipini, Dimitra Plested, Emma Pluess-Hall, Helen Pollock, Katrina Poulton, Ian Presland, Laura Provstgaard-Morys, Samuel Pulido, David Radia, Kajal Ramos Lopez, Fernando Rand, Jade Ratcliffe, Helen Rawlinson, Thomas Rhead, Sarah Riddell, Amy Ritchie, Adam John Roberts, Hannah Robson, Joanna Roche, Sophie Rohde, Cornelius Rollier, Christine S. Romani, Rossana Rudiansyah, Indra Saich, Stephen Sajjad, Sara Salvador, Stephannie Sanchez Riera, Lidia Sanders, Helen Sanders, Katherine Sapaun, Shari Sayce, Chloe Schofield, Ella Screaton, Gavin Selby, Beatrice Semple, Calum Sharpe, Hannah R. Shaik, Imam Shea, Adam Shelton, Holly Silk, Sarah Silva-Reyes, Laura Skelly, Donal T. Smee, Heather Smith, Catherine C. Smith, David J. Song, Rinn Spencer, Alexandra J. Stafford, Elizabeth Steele, Amy Stefanova, Elena Stockdale, Lisa Szigeti, Anna Tahiri-Alaoui, Abdessamad Tait, Moira Talbot, Helen Tanner, Rachel Taylor, Iona Jennifer Taylor, Victoria Te Water Naude, Rebecca Thakur, Nazia Themistocleous, Yrene Themistocleous, Andreas Thomas, Merin Thomas, Tonia M. Thompson, Amber Thomson-Hill, Samantha Tomlins, Jennifer Tonks, Susan Towner, James Tran, Nguyen Tree, Julia A. Truby, Adam Turkentine, Kate Turner, Cheryl Turner, Nicola Turner, Sally Tuthill, Toby Ulaszewska, Marta Varughese, Rachel Van Doremalen, Neeltje Veighey, Kristin Verheul, Marije K. Vichos, Iason Vitale, Elia Walker, Laura Watson, Marion E.E. Welham, Benjamin Wheat, Julie White, Caroline White, Rachel Worth, Andrew T. Wright, Danny Wright, Suzie Yao, Xin Li Yau, Yasmine
Source :
The Lancet; August 2020, Vol. 396 Issue: 10249 p467-478, 12p
Publication Year :
2020
Abstract
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and immunogenicity of a viral vectored coronavirus vaccine that expresses the spike protein of SARS-CoV-2.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
396
Issue :
10249
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs53840860
Full Text :
https://doi.org/10.1016/S0140-6736(20)31604-4