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Circular RNA cir-ITCHPromotes Osteosarcoma Migration and Invasion through cir-ITCH/miR-7/EGFR Pathway
- Source :
- Technology in Cancer Research & Treatment; July 2020, Vol. 19 Issue: 1
- Publication Year :
- 2020
-
Abstract
- Recent studies have suggested that circular RNAs play an important role in the progression of various cancers. We aimed to investigate the possible role of cir-ITCHin osteosarcoma. In this study, we performed experiments with the human osteoblast cell line hFOB1.19 and several osteosarcoma cancer cell lines and the results showed that the expression of cir-ITCHin osteosarcoma cancer cell lines was significantly upregulated compared to that in the human osteoblast cell line. In addition, the results showed that cir-ITCHcould promote the migration, invasion, and growth of osteosarcoma cells. Further mechanistic studies revealed that cir-ITCHcould enhance epidermal growth factor receptor (EGFR) expression by reducing the level of miR-7. Increased EGFR phosphorylation was found to be concomitant with high expression of EGFR. We determined that cir-ITCH-mediated increase in the migration and invasion of osteosarcoma cells was dependent on EGFR phosphorylation. In conclusion, our research uncovered an important role of the cir-ITCH/miR-7/EGFR pathway in the migration and invasion of osteosarcoma cells and suggested that cir-ITCHmay be a prognostic marker and a promising therapeutic target for osteosarcoma.
Details
- Language :
- English
- ISSN :
- 15330346 and 15330338
- Volume :
- 19
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Technology in Cancer Research & Treatment
- Publication Type :
- Periodical
- Accession number :
- ejs53675535
- Full Text :
- https://doi.org/10.1177/1533033819898728