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Macromolecular modeling and design in Rosetta: recent methods and frameworks
- Source :
- Nature Methods; July 2020, Vol. 17 Issue: 7 p665-680, 16p
- Publication Year :
- 2020
-
Abstract
- The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactored and extended. Its advantages are its performance and interoperability between broad modeling capabilities. Here we review tools developed in the last 5 years, including over 80 methods. We discuss improvements to the score function, user interfaces and usability. Rosetta is available at http://www.rosettacommons.org.
Details
- Language :
- English
- ISSN :
- 15487091 and 15487105
- Volume :
- 17
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Nature Methods
- Publication Type :
- Periodical
- Accession number :
- ejs53375093
- Full Text :
- https://doi.org/10.1038/s41592-020-0848-2