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Remote and Selective C(sp2)–H Olefination for Sequential Regioselective Linkage of Phenanthrenes
- Source :
- Organic Letters; June 2020, Vol. 22 Issue: 11 p4129-4134, 6p
- Publication Year :
- 2020
-
Abstract
- Biphenylcarboxylic acid with two competing C(sp2)-H sites was designed for site selective C(sp2)-H functionalization by developing carboxylic acids assisted remote and selective olefination via 7-membered palladacycle. Mechanism investigation and DFT calculations reveal a kinetics-determined process, which could be utilized to explore a variety of remote site selectivity. The practicability of this method was highlighted by the precise construction of phenathrene under sequential site selectivity.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 22
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs53337803
- Full Text :
- https://doi.org/10.1021/acs.orglett.0c01208