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Preclinical Development and Assessment of Viral Vectors Expressing a Fusion Antigen of Plasmodium falciparumLSA1 and LSAP2 for Efficacy against Liver-Stage Malaria
- Source :
- Infection and Immunity; November 2019, Vol. 88 Issue: 2
- Publication Year :
- 2019
-
Abstract
- Despite promising progress in malaria vaccine development in recent years, an efficacious subunit vaccine against Plasmodium falciparumremains to be licensed and deployed. Cell-mediated protection from liver-stage malaria relies on a sufficient number of antigen-specific T cells reaching the liver during the time that parasites are present. A single vaccine expressing two antigens could potentially increase both the size and breadth of the antigen-specific response while halving vaccine production costs.
Details
- Language :
- English
- ISSN :
- 00199567 and 10985522
- Volume :
- 88
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Infection and Immunity
- Publication Type :
- Periodical
- Accession number :
- ejs53330111
- Full Text :
- https://doi.org/10.1128/IAI.00573-19