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Stp1 Loss of Function Promotes β-Lactam Resistance in Staphylococcus aureusThat Is Independent of Classical Genes
- Source :
- Antimicrobial Agents and Chemotherapy; March 2020, Vol. 64 Issue: 6
- Publication Year :
- 2020
-
Abstract
- β-Lactam resistance in Staphylococcus aureuslimits treatment options. Stp1 and Stk1, a serine-threonine phosphatase and kinase, respectively, mediate serine-threonine kinase (STK) signaling. Loss-of-function point mutations in stp1were detected among laboratory-passaged β-lactam-resistant S. aureusstrains lacking mecAand blaZ, the major determinants of β-lactam resistance in the bacteria.
Details
- Language :
- English
- ISSN :
- 00664804 and 10986596
- Volume :
- 64
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Antimicrobial Agents and Chemotherapy
- Publication Type :
- Periodical
- Accession number :
- ejs53318634
- Full Text :
- https://doi.org/10.1128/AAC.02222-19