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Comparison of extubation success using noninvasive positive pressure ventilation (NIPPV) versus noninvasive neurally adjusted ventilatory assist (NI-NAVA)
- Source :
- Journal of Perinatology; August 2020, Vol. 40 Issue: 8 p1202-1210, 9p
- Publication Year :
- 2020
-
Abstract
- Objective: Compare rates of initial extubation success in preterm infants extubated to NIPPV or NI-NAVA. Study design: In this pilot study, we randomized 30 mechanically ventilated preterm infants at the time of initial elective extubation to NI-NAVA or NIPPV in a 1:1 assignment. Primary study outcome was initial extubation success. Results: Rates of continuous extubation for 120 h were 92% in the NI-NAVA group and 69% in the NIPPV group (12/13 vs. 9/13, respectively, p= 0.14). Infants extubated to NI-NAVA remained extubated longer (median 18 vs. 4 days, p= 0.02) and experienced lower peak inspiratory pressures (PIP) than infants managed with NIPPV throughout the first 3 days after extubation. Survival analysis through 14 days post extubation showed a sustained difference in the primary study outcome until 12 days post extubation. Conclusions: Our study is the first to suggest that a strategy of extubating preterm infants to NI-NAVA may be more successful.
Details
- Language :
- English
- ISSN :
- 07438346 and 14765543
- Volume :
- 40
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Journal of Perinatology
- Publication Type :
- Periodical
- Accession number :
- ejs53245118
- Full Text :
- https://doi.org/10.1038/s41372-019-0578-4