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Significance of P16INK4Ahypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study
- Source :
- Annals of Oncology; June 2006, Vol. 17 Issue: 1, Number 1 Supplement 7 pvii137-vii141, 5p
- Publication Year :
- 2006
-
Abstract
- Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivation; its incidence is extremely variable according to the type of tumor involved. Our purpose was to analyze the hypermethylation of the p16 promoter in laryngeal squamous cell carcinomas (LSCC), salivary gland (SG) tumors and in colorectal cancer (CRC), to detect any possible association with the clinicopathological features and to determine the prognostic significance of the p16 gene in the tumors analyzed.
Details
- Language :
- English
- ISSN :
- 09237534 and 15698041
- Volume :
- 17
- Issue :
- 1, Number 1 Supplement 7
- Database :
- Supplemental Index
- Journal :
- Annals of Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs53236279
- Full Text :
- https://doi.org/10.1093/annonc/mdl967