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Adjuvant 131I-metuximab for hepatocellular carcinoma after liver resection: a randomised, controlled, multicentre, open-label, phase 2 trial

Authors :
Li, Jun
Xing, Jingliang
Yang, Yefa
Liu, Jingfeng
Wang, Wentao
Xia, Yong
Yan, Zhenlin
Wang, Kui
Wu, Dong
Wu, Lu
Wan, Xuying
Yang, Tian
Gao, Chunfang
Si, Anfeng
Wang, Hongyang
Wu, Mengchao
Lau, Wan Yee
Chen, Zhinan
Shen, Feng
Source :
The Lancet Gastroenterology & Hepatology; June 2020, Vol. 5 Issue: 6 p548-560, 13p
Publication Year :
2020

Abstract

Effective adjuvant treatment after hepatectomy for hepatocellular carcinoma (HCC) is an important area of research. Radioactive iodine (131I)-labelled metuximab is a radiolabelled monoclonal antibody against the CD147 (also known as basigin or HAb18G) antigen that is expressed in HCC. We aimed to examine the role of 131I-metuximab as an adjuvant therapy after HCC resection.

Details

Language :
English
ISSN :
24681253
Volume :
5
Issue :
6
Database :
Supplemental Index
Journal :
The Lancet Gastroenterology & Hepatology
Publication Type :
Periodical
Accession number :
ejs53235937
Full Text :
https://doi.org/10.1016/S2468-1253(19)30422-4