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CAR T cells and checkpoint inhibition for the treatment of glioblastoma
- Source :
- Expert Opinion on Biological Therapy; June 2020, Vol. 20 Issue: 6 p579-591, 13p
- Publication Year :
- 2020
-
Abstract
- ABSTRACTIntroduction: Glioblastoma (GBM) is a highly aggressive brain tumor and is one of the most lethal human cancers. Chimeric antigen receptor (CAR) T cell therapy has markedly improved survival in previously incurable disease; however, this vanguard treatment still faces challenges in GBM. Likewise, checkpoint blockade therapies have not enjoyed the same victories against GBM. As it becomes increasingly evident that a mono-therapeutic approach is unlikely to provide anti-tumor efficacy, there evolves a critical need for combined treatment strategies.Areas covered: This review highlights the clinical successes observed with CAR T cell therapy as well the current efforts to overcome its perceived limitations. The review also explores employed combinations of CAR T cell approaches with immune checkpoint blockade strategies, which aim to potentiate immunotherapeutic benefits while restricting the impact of tumor heterogeneity and T cell exhaustion.Expert opinion: Barriers such as tumor heterogeneity and T cell exhaustion have exposed the weaknesses of various mono-immunotherapeutic approaches to GBM, including CAR T cell and checkpoint blockade strategies. Combining these potentially complementary strategies, however, may proffer a rational means of mitigating these barriers and advancing therapeutic successes against GBM and other solid tumors.
Details
- Language :
- English
- ISSN :
- 14712598 and 17447682
- Volume :
- 20
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Expert Opinion on Biological Therapy
- Publication Type :
- Periodical
- Accession number :
- ejs53182682
- Full Text :
- https://doi.org/10.1080/14712598.2020.1727436