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Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study
Authors :
Ober, Carole McKennan, Chris G Magnaye, Kevin M Altman, Matthew C Washington, Charles Stanhope, Catherine Naughton, Katherine A Rosasco, Mario G Bacharier, Leonard B Billheimer, Dean Gold, Diane R Gress, Lisa Hartert, Tina Havstad, Suzanne Khurana Hershey, Gurjit K Hallmark, Brian Hogarth, D Kyle Jackson, Daniel J Johnson, Christine C Kattan, Meyer Lemanske, Robert F Lynch, Susan V Mendonca, Eneida A Miller, Rachel L Naureckas, Edward T O'Connor, George T Seroogy, Christine M Wegienka, Ganesa White, Steven R Wood, Robert A Wright, Anne L Zoratti, Edward M Martinez, Fernando D Ownby, Dennis Nicolae, Dan L Levin, Albert M Gern, James E Achten, Niek Ainsworth, John Akkerman, Nonna Anderson, Elizabeth Anderson, Larry J. Andrews, Howard Armagost, Elizabeth Aubuchon, Mary Ann Bach, Julia Bacharier, Leonard Barnes, Kathrine L. Barone, Charles Bauer, Irma Beamer, Paloma Becker, Patrice Bednarek, Alyssa Bellemore, Stacey Bendixsen, Casper G. Biagini Myers, Jocelyn M. Billheimer, Dean Billstrand, Christine Birg, Geraldine Blocki, Shirley Bloomberg, Gordon Bobbitt, Kevin Bochkov, Yury Bourgeois, Karen Boushey, Homer Brockman-Schneider, Rebecca Brunwasser, Steven M. Budrevich, Richard Burkle, Jeffrey W. Busse, William Calatroni, Agustin Campbell, Janice Carlson-Dakes, Kirsten Cassidy-Bushrow, Andrea Chappell, James D. Chasman, Deborah Chipps, Teresa M. Chirkova, Tatiana Cole, Deanna Connolly, Alexandra Cootauco, Michelle Cootauco, Michelle Costello, Kaitlin Couch, Philip Coull, Brent Craven, Mark Crisafi, Gina Cruikshank, William Curtsinger, Kristi Custovic, Adnan Das, Suman R. DaSilva, Douglas Datta, Soma Davidson, Brent De La Ossa, Lydia DeVries, Mark Di, Qian Dixon, Samara Donnerbauer, Erin Dorst, Marian Doyle, Susan Dresen, Amy Dupont, William D. Durrange, Janet Erickson, Heidi Evans, Michael D. Ezell, Jerel Farnham, Leanna Filardo-Collins, Roxanne Finazzo, Salvatore Flege, Zachary Fleurat, Conner Floerke, Heather Floerke, Dorothy Foss, Terry Freie, Angela Frome, Wayne Fye, Samantha Gagalis, Lisa Gammell, Rebecca Gangnon, Ronald E. Ge, James E. Gebretsadik, Tebeb Gergen, Peter Gern, James E. Gibson, Heike Gjerasi, Edlira Gold, Diane R. Gonzalez, Nicole Goodman, Kayla Gress, Lisa Grindle, Kristine Groeschen, Taylor Hallmark, Brian Halonen, Marilyn Hart, Jaime Hartert, Tina V. Havstad, Suzanne Heinritz, Patrick Hensley Alford, Sharon Herbstman, Julie Hernandez, Kellie Hoepner, Lori Jackson, Daniel J. Jadhao, Samadhan J. Jaffee, Katy James, Peter Jezioro, Jacqueline Jimenez Pescador, Marcia Johnson, Christine C. Johnson, Tara Johnson, Camille Jones, Amelia Jones, Kyra Jones, Paul Jordan, Carolina Joseph, Christine LM Kattan, Meyer Keidel, Kristina Keifer, Matthew C. Kelley, Rick Khurana Hershey, Gurgit K. Kim, Haejin Kloog, Itai Koepel, Tammy Kronenwetter Koerkenmeier, Clint Ladick, Laura Lamm, Carin Larkin, Emma Lederman, Howard Lee-Parritz, Aviva Leimenstoll, Stephanie Lemanske, Robert F. LeMasters, Grace K. Levin, Albert M. Levine, Jessica Liu, Xinhua Liu, Zhouwen Lopez, Silvia Lothrop, Nathan Lovinsky-Desir, Stephanie Lukacs, Nicholas Lynch, Susan Lynch, Christian Mann, Erik Martin, Jennifer Martin, Lisa Martinez, Fernando D. Matsui, Elizabeth McCauley, Katherine Mccollum, Megan McCullough, Judith McKennon, Chris G. Meece, Jennifer Mendonca, Eneida Mikus, Lance Miller, Rachel L. Minton, Patricia Mitchell, Herman Moon, Vicki Moore, Paul E. Morgan, Wayne Morgan, Valerie Morgan, David Murrison, Liza Nicholas, Charlotte Nicolae, Daniel Nunez, Adam O'Connor, George O'Toole, Sharon Ober, Carole Olson, Brent F. Ong, Irene Osmundson, Sarah Ownby, Dennis Pappas, Tressa Perera, Frederica Perzanowski, Matthew Peterson, Edward Pierce, Marcela Price-Johnson, Penny Rajamanickam, Victoria Ramirez, Judyth Ray, Kimberly Renneberg, Megan Requia, Weeberb Riley, Kylie Rivera, Janelle Rivers, Neisha Roberg, Kathy Rogers, Theresa Rosas-Salazar, Christian Russell, Pat Ryan, Patrick H. Sadovsky, Yoel Salazar, Lisa Sampson, Hugh Sandel, Megan Schoettler, Nathan Schwartz, Joel Scott, Dena Seroogy, Christine M. Sharp, Renee Shilts, Meghan H. Sigelman, Steve Singh, Anne Marie Sitarik, Alexandra Smartt, Ernestine Sorkness, Ronald Sorkness, Christine Spangenberg, Amber Sperling, Rhoda Spies, David Stern, Debra A. Stoffel, Brandy Peebles, R. Stokes Stouffer, Gina Strauchman Boyer, Cathey Suddeuth, Caitlin Tachinardi, Umberto Tang, Deliang Tang, Zhengzheng Tate, Jena Taylor, William Tensing, Krista Tesson, Elizabeth Thompson, Kathy Thompson, Emma Tisler, Christopher Togias, Alkis Turi, Kedir Turner, Victoria Tuzova, Marina VanWormer, Jeffrey J. Visness, Cynthia M. Vrtis, Rose Wahlman, Anthony Wang, Lena Wegienka, Ganesa Wells, Karen Wentworth-Sheilds, William Wheatley, Lisa Whitney, Nitsa Williams, L. Keoki Witter, Frank Wolfe, Christopher Wood, Robert A. Woodcroft, Kimberley Woodward, Kim B. Wright, Anne L. Wright, Rosalind Wu, Pingsheng Yaeger, Melissa Yaniv, Perri Zanobetti, Antonella Zhang, Shirley Zook, Patricia Zoratti, Edward M.
Source :
The Lancet Respiratory Medicine; May 2020, Vol. 8 Issue: 5 p482-492, 11p
Publication Year :
2020
Abstract
African ancestry is associated with a higher prevalence and greater severity of asthma than European ancestries, yet genetic studies of the most common locus associated with childhood-onset asthma, 17q12–21, in African Americans have been inconclusive. The aim of this study was to leverage both the phenotyping of the Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium, and the reduced linkage disequilibrium in African Americans, to fine map the 17q12–21 locus.
Details
Language :
English
ISSN :
22132600 and 22132619
Volume :
8
Issue :
5
Database :
Supplemental Index
Journal :
The Lancet Respiratory Medicine
Publication Type :
Periodical
Accession number :
ejs53151976
Full Text :
https://doi.org/10.1016/S2213-2600(20)30011-4