Clinical and patient determinants of changing therapy in relapsing-remitting multiple sclerosis (SWITCH study)

•The introduction of increasingly effective treatments has changed the MS scenario.•This study investigated the reasons that brought about modification of treatment.•In our study, out of 13,657 patients, 336 (3%) modified treatment.•90.2% switched, 8.9% temporarily discontinued, and 0.9% permanently discontinued.•Efficacy remains the main driving force behind switching in 58.4% of patients.