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De novo appearance of the ph-1 chromosome in a previously monosomic bone marrow (45,XX,-6): conversion of a myeloproliferative disorder to acute myelogenous leukemia
- Source :
- Blood; May 1975, Vol. 45 Issue: 5 p653-657, 5p
- Publication Year :
- 1975
-
Abstract
- Bone marrow examination of a patient with a myeloproliferative disorder revealed monosomy for chromosome No. 6 (45,XX,-6). Two months later, during blastic crisis, reinvestigation of the bone marrow showed the presence of the Ph-1 chromosome in the previously aneuploid cell line (45,XX,-6,-22,+Ph-1). This case differs from those previously published in that the Ph-1 chromosome appeared de novo during the development of frank acute myelogenous leukemia.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 45
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs53089279
- Full Text :
- https://doi.org/10.1182/blood.V45.5.653.653