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Weight of epidemiological evidence for titanium dioxide risk assessment: current state and further needs

Authors :
Guseva Canu, Irina
Fraize-Frontier, Sandrine
Michel, Cécile
Charles, Sandrine
Source :
Journal of Exposure Science and Environmental Epidemiology; May 2020, Vol. 30 Issue: 3 p430-435, 6p
Publication Year :
2020

Abstract

We address here the importance of epidemiological evidence in risk assessment and decision-making in Europe. To illustrate this, titanium dioxide (TiO2) was used as a model compound. TiO2is widely used as an odorless white pigment and opacifying agent. A recent systematic review assessing the weight of evidence on the relationship between exposure to TiO2(all forms) and cancer in humans questions the assumptions that TiO2is an inert material of low toxicity. Based on this new data, France submitted a proposal to classify TiO2as a possible human carcinogen under the European regulation. The European Chemicals Agency Risk assessment committee concluded that TiO2(all forms) warrants a classification as a suspected human carcinogen via inhalation (Category-2) under the CLP regulation (for Classification, Labeling and Packaging of chemicals). No considerations was given to TiO2particle size, which may affect human health effects. Consequently, further epidemiological studies are needed to assess possible associations between different physical–chemical characteristics of TiO2exposures and their impact on human health. This would allow strengthening the evidence on which to build the most appropriate regulation and to guaranty safe use given any exposure route of any TiO2particle shape or size.

Details

Language :
English
ISSN :
15590631 and 1559064X
Volume :
30
Issue :
3
Database :
Supplemental Index
Journal :
Journal of Exposure Science and Environmental Epidemiology
Publication Type :
Periodical
Accession number :
ejs53070219
Full Text :
https://doi.org/10.1038/s41370-019-0161-2