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High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients
- Source :
- Blood; February 2003, Vol. 101 Issue: 3 p837-845, 9p
- Publication Year :
- 2003
-
Abstract
- The proto-oncogene EVI1 encodes a DNA binding protein and is located on chromosome 3q26. The gene is aberrantly expressed in acute myeloid leukemia (AML) patients carrying 3q26 abnormalities. Two mRNAs are transcribed from this locus: EVI1 and a fusion ofEVI1 with MDS1(MDS1-EVI1), a gene located 5′ ofEVI1. The purpose of this study was to investigate which of the 2 gene products is involved in transformation in human AML. To discriminate between EVI1 andMDS1-EVI1 transcripts, distinct real-time quantitative polymerase chain reaction (PCR) assays were developed. Patients with 3q26 abnormalities often showed highEVI1 and MDS1-EVI1 expression. In a cohort of 319 AML patients, 4 subgroups could be distinguished:EVI1+ andMDS1-EVI1− (6 patients; group I), EVI1+ andMDS1-EVI1+ (26 patients; group II),EVI1− andMDS1-EVI1+ (12 patients; group III), and EVI1− andMDS1-EVI1− (275 patients; group IV). The only 4 patients with a 3q26 aberration belonged to groups I and II. Interestingly, high EVI1 and notMDS1-EVI1 expression was associated with unfavorable karyotypes (eg, −7/7q−) or complex karyotypes. Moreover, a significant correlation was observed betweenEVI1 expression and 11q23 aberrations (mixed lineage leukemia [MLL] gene involvement). Patients from groups I and II had significantly shorter overall and event-free survival than patients in groups III and IV. Our data demonstrate that highEVI1 expression is an independent poor prognostic marker within the intermediate- risk karyotypic group.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 101
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs53012448
- Full Text :
- https://doi.org/10.1182/blood-2002-05-1459