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FTY720 Restores PP2A Tumor Suppressor Activity in Polycythemia Vera CD34+ Progenitors Through Inhibition of Jak2 V617F- and PI-3Kγ-Dependent SET Serine Phosphorylation and Enhancement of NOS-Dependent PP2A Tyrosine Nitration

Authors :
Oaks, Joshua J
Mukhopadhyay, A.
Santhanam, Ramasamy
Saddoughi, S. A
Neviani, Paolo
Harb, Jason G
Ogretmen, Besim
Bittman, Robert
Levine, Ross L
Quintás-Cardama, Alfonso
Marcucci, Guido
Perrotti, Danilo
Source :
Blood; November 2011, Vol. 118 Issue: 21 p2494-2494, 1p
Publication Year :
2011

Abstract

No relevant conflicts of interest to declare.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
118
Issue :
21
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs52983993
Full Text :
https://doi.org/10.1182/blood.V118.21.2494.2494