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The Characterization of Hemoglobin Shimonoseki
- Source :
- Blood; November 1964, Vol. 24 Issue: 5 p624-635, 12p
- Publication Year :
- 1964
-
Abstract
- Hemoglobin Shimonoseki, discovered in western Japan in 1960, has been further characterized as a mutant with abnormal α-polypeptide chains on the basis of: (1) The presence of a minor hemoglobin component migrating cathodally at pH 8.6 to Hb A2, presumably α2Shσ2A2. (2) Hybridization studies. (3) Fingerprinting of isolated α-polypeptide chains. Hemoglobin Sh is characterized by the substitution of arginine for glutamine at residue 54 and can therefore be designated as α254Argβ2A.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 24
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs52954942
- Full Text :
- https://doi.org/10.1182/blood.V24.5.624.624