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Antithrombin "Chicago": a functionally abnormal molecule with increased heparin affinity causing familial thrombophilia
- Source :
- Blood; December 1983, Vol. 62 Issue: 6 p1242-1250, 9p
- Publication Year :
- 1983
-
Abstract
- A family with a high incidence of spontaneous thromboembolism over four generations has been investigated. The propositus is a 21-yr-old male with a history of thrombophlebitis. Medical histories of 46 family members were obtained. Twelve of these individuals have experienced deep venous thromboses and/or pulmonary emboli. Seven members of the kindred, with a prior history of thrombotic phenomena, were investigated in detail. These subjects were found to have normal plasma concentrations of immunoreactive antithrombin (mean 96%), decreased plasma levels of progressive antithrombin activity (mean 50%), and greatly reduced amounts of plasma heparin cofactor activity (mean 42%). The abnormal antithrombin (“Chicago”) was found to elute from heparin- Sepharose at a higher ionic strength than normal inhibitor. The functionally defective antithrombin molecules exhibit a reduced ability to neutralize thrombin in the presence or absence of heparin (approximately 10%-20% of normal). The molecular defect of this protease inhibitor thus appears to be distinct from those of previously described abnormal antithrombins.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 62
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs52894377
- Full Text :
- https://doi.org/10.1182/blood.V62.6.1242.1242