Back to Search
Start Over
Carnosine-Modified Fullerene as a Highly Enhanced ROS Scavenger for Mitigating Acute Oxidative Stress
- Source :
- ACS Applied Materials & Interfaces; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- Fullerenes are known as highly efficient scavengers for reactive oxygen species (ROSs). In this study, a carnosine-modified fullerene derivative (C60–Car) was synthesized via a one-step nucleophilic addition reaction. C60–Car forms nanoparticles (NPs) readily in water at neutral pH and room temperature through self-assembly. The C60–Car NPs were found to possess good water solubility, biocompatibility, and excellent ROSs scavenging capability. The scavenging efficiency of ROSs is as high as 92.49% and significantly better than that of hydroxyfullerene (C60–OH NPs, 70.92%) and l-carnosine. Furthermore, C60–Car NPs showed strong cytoprotective ability against H2O2-induced damage to the normal human fetal hepatocyte cells (L-02) and human epidermal keratinocytes-adult (HEK-a) cells at a lower concentration of 2.5 μM. In contrast, C60–OH NPs showed a minor cytoprotective effect on cells at a high concentration of 10 μM. The excellent properties of such a fullerene derivative, C60–Car, can be attributed largely to the involvement of l-carnosine with biological activity and antioxidant property, which make it better for biomedicine, and it may provide a new strategy for mitigating acute oxidative stress based on fullerene materials.
Details
- Language :
- English
- ISSN :
- 19448244
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- ACS Applied Materials & Interfaces
- Publication Type :
- Periodical
- Accession number :
- ejs52731706
- Full Text :
- https://doi.org/10.1021/acsami.0c01669