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Increased Chitotriosidase Is Associated With Aspergillusand Frequent Exacerbations in South-East Asian Patients With Bronchiectasis

Authors :
Poh, Tuang Yeow
Tiew, Pei Yee
Lim, Albert Yick Hou
Thng, Kai Xian
Binte Mohamed Ali, Nur A’tikah
Narayana, Jayanth Kumar
Mac Aogáin, Micheál
Tien, Zhijun
Chew, Wui Mei
Wai Chan, Adrian Kwok
Keir, Holly R.
Dicker, Alison J.
Hassan, Tidi Maharani
Xu, Huiying
Tee, Augustine K.H.
Ong, Thun How
Koh, Mariko Siyue
Abisheganaden, John Arputhan
Chalmers, James D.
Chotirmall, Sanjay H.
Source :
Chest; August 2020, Vol. 158 Issue: 2 p512-522, 11p
Publication Year :
2020

Abstract

Chitinase activity is an important innate immune defence mechanism against infection that includes fungi. The 2 human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase are associated to allergy, asthma, and COPD; however, their role in bronchiectasis and bronchiectasis-COPD overlap (BCO) is unknown.

Details

Language :
English
ISSN :
00123692 and 19313543
Volume :
158
Issue :
2
Database :
Supplemental Index
Journal :
Chest
Publication Type :
Periodical
Accession number :
ejs52707573
Full Text :
https://doi.org/10.1016/j.chest.2020.02.048