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Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Authors :
Vizioli, Maria Grazia
Liu, Tianhui
Miller, Karl N.
Robertson, Neil A.
Gilroy, Kathryn
Lagnado, Anthony B.
Perez-Garcia, Arantxa
Kiourtis, Christos
Dasgupta, Nirmalya
Lei, Xue
Kruger, Patrick J.
Nixon, Colin
Clark, William
Jurk, Diana
Bird, Thomas G.
Passos, João F.
Berger, Shelley L.
Dou, Zhixun
Adams, Peter D.
Source :
Genes & Development; 2020, Vol. 34 Issue: 5-6 p428-445, 18p
Publication Year :
2020

Abstract

In this study, Vizioli et al. investigated the upstream signaling events that promote cytoplasmic formation of chromatin fragments (CCFs), which are extruded from the nucleus of senescent cells and trigger the senescence-associated secretory phenotype (SASP). They show that dysfunctional mitochondria, linked to down-regulation of nuclear-encoded mitochondrial oxidative phosphorylation genes, trigger a ROS–JNK retrograde signaling pathway that drives CCF formation and hence the SASP.

Details

Language :
English
ISSN :
08909369 and 15495477
Volume :
34
Issue :
5-6
Database :
Supplemental Index
Journal :
Genes & Development
Publication Type :
Periodical
Accession number :
ejs52566587
Full Text :
https://doi.org/10.1101/gad.331272.119