Back to Search
Start Over
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
- Source :
- Genes & Development; 2020, Vol. 34 Issue: 5-6 p428-445, 18p
- Publication Year :
- 2020
-
Abstract
- In this study, Vizioli et al. investigated the upstream signaling events that promote cytoplasmic formation of chromatin fragments (CCFs), which are extruded from the nucleus of senescent cells and trigger the senescence-associated secretory phenotype (SASP). They show that dysfunctional mitochondria, linked to down-regulation of nuclear-encoded mitochondrial oxidative phosphorylation genes, trigger a ROS–JNK retrograde signaling pathway that drives CCF formation and hence the SASP.
Details
- Language :
- English
- ISSN :
- 08909369 and 15495477
- Volume :
- 34
- Issue :
- 5-6
- Database :
- Supplemental Index
- Journal :
- Genes & Development
- Publication Type :
- Periodical
- Accession number :
- ejs52566587
- Full Text :
- https://doi.org/10.1101/gad.331272.119