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HEARTBiT: A Transcriptomic Signature for Excluding Acute Cellular Rejection in Adult Heart Allograft Patients

Authors :
Shannon, Casey P.
Hollander, Zsuzsanna
Dai, Darlene L.Y.
Chen, Virginia
Assadian, Sara
Lam, Karen K.
McManus, Janet E.
Zarzycki, Marek
Kim, YoungWoong
Kim, Ji-Young V.
Balshaw, Robert
Gidlöf, Olof
Öhman, Jenny
Smith, J. Gustav
Toma, Mustafa
Ignaszewski, Andrew
Davies, Ross A.
Delgado, Diego
Haddad, Haissam
Isaac, Debra
Kim, Daniel
Mui, Alice
Rajda, Miroslaw
West, Lori
White, Michel
Zieroth, Shelley
Tebbutt, Scott J.
Keown, Paul A.
McMaster, W. Robert
Ng, Raymond T.
McManus, Bruce M.
Source :
Canadian Journal of Cardiology; August 2020, Vol. 36 Issue: 8 p1217-1227, 11p
Publication Year :
2020

Abstract

Nine mRNA transcripts associated with acute cellular rejection (ACR) in previous microarray studies were ported to the clinically amenable NanoString nCounter platform. Here we report the diagnostic performance of the resulting blood test to exclude ACR in heart allograft recipients: HEARTBiT.

Details

Language :
English
ISSN :
0828282X
Volume :
36
Issue :
8
Database :
Supplemental Index
Journal :
Canadian Journal of Cardiology
Publication Type :
Periodical
Accession number :
ejs52558386
Full Text :
https://doi.org/10.1016/j.cjca.2019.11.017