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Silencing synapses

Authors :
Caleo, Matteo
Restani, Laura
Perry, V. Hugh
Source :
Prion; March 2013, Vol. 7 Issue: 2 p147-150, 4p
Publication Year :
2013

Abstract

The degeneration of pre-synaptic boutons in the stratum radiatum of the dorsal hippocampus is one of earliest components of neurodegeneration in several models of murine prion disease. We recently showed that blockade of synaptic transmission by infusion of botulinum neurotoxin A (BoNT/A) into the hippocampus several weeks prior to the onset of degeneration, had no detectable impact on the extent of the synaptic degeneration.1We elaborate here on the rationale for these experiments and highlight why we believe that this negative result is interesting and important. We also discuss new observations that might provide insights into the molecular events that underlie synapse degeneration.

Details

Language :
English
ISSN :
19336896 and 1933690X
Volume :
7
Issue :
2
Database :
Supplemental Index
Journal :
Prion
Publication Type :
Periodical
Accession number :
ejs52524180
Full Text :
https://doi.org/10.4161/pri.23327