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The usefulness of monitored therapy using Clozapine concentration in the blood serum for determining drug dose in Polish schizophrenic patients
- Source :
- Pharmacological Reports; November 2016, Vol. 68 Issue: 6 p1120-1125, 6p
- Publication Year :
- 2016
-
Abstract
- Background: The aim of the study is to evaluate the advisability of systematic monitoring of clozapine (CLO) concentration in serum during treatment of schizophrenia in Polish psychiatric patients. Method: The concentration of CLO and its metabolites: norclozapine (NCLO) and clozapine N-oxide (CLO-NO) in serum obtained from 107 patients suffering from schizophrenia was determined by high performance liquid chromatography (HPLC) method. There were two groups of patients. In the first group of patients (n = 95) the concentration of drug and its metabolites was determined by one-time testing. Correlations were tested using the test statistics. In the second group of patients (n = 12), 51 samples of serum were provided by the same patient in different time spans (from 6 days to 14 months after the beginning of the treatment). Results: Concentrations of CLO and its metabolites in blood serum do not always show a linear dependence on the applied dose for individual patients. Conclusion: The high volatility of CLO concentrations in blood serum of patients treated with identical doses of the drug confirmed the validity of the monitored therapy.
Details
- Language :
- English
- ISSN :
- 17341140 and 22995684
- Volume :
- 68
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Pharmacological Reports
- Publication Type :
- Periodical
- Accession number :
- ejs52298800
- Full Text :
- https://doi.org/10.1016/j.pharep.2016.06.016