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Interaction Proteomics Identifies ERbeta Association with Chromatin Repressive Complexes to Inhibit Cholesterol Biosynthesis and Exert An Oncosuppressive Role in Triple-negative Breast Cancer*
- Source :
- Molecular and Cellular Proteomics (MCP Online); February 2020, Vol. 19 Issue: 2 p245-260, 16p
- Publication Year :
- 2020
-
Abstract
- Triple-negative breast cancers (TNBCs) are characterized by low overall survival and poor response to therapy because of their aggressiveness and limited available treatments. We found a subset of TNBC expressing the master regulator estrogen receptor beta (ERβ1) and characterized the effect of this nuclear receptor in human TNBC cells by a multiomics approach. Results highlight transcriptome deregulation by ERβ involving association with chromatin remodeling complexes, including PRC1/2, and provide an explanation for its oncosuppressive effects on TNBC cells.
Details
- Language :
- English
- ISSN :
- 15359476 and 15359484
- Volume :
- 19
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Molecular and Cellular Proteomics (MCP Online)
- Publication Type :
- Periodical
- Accession number :
- ejs52276357
- Full Text :
- https://doi.org/10.1074/mcp.RA119.001817