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Investigating the effect of freezing temperature and cross-linking on modulating drug release from chitosan scaffolds

Authors :
Dathathri, Eshwari
Thakur, Goutam
Koteshwara, K. B.
Anil Kumar, N. V.
Rodrigues, Fiona Concy
Source :
Chemical Papers; 20240101, Issue: Preprints p1-10, 10p
Publication Year :
2024

Abstract

The aim of this study was to investigate the effect of altering design variables like cross-linking and freezing temperature (at a time) on morphology of freeze-dried chitosan scaffolds and modulation of release of Diclofenac sodium (model drug). Freeze-dried chitosan scaffolds produced at − 80 °C, cross-linked with genipin, showed swelling of 163.52 ± 9.95% with sustained drug release of 26.37 ± 10.47% over 24 h (P< 0.05). In comparison, uncross-linked scaffolds produced at − 80 °C showed higher swelling of 173.58 ± 8.23% and drug release of 28.67 ± 2.40% (P< 0.05). Uncross-linked scaffolds produced using freezing temperature of − 20 °C also showed higher swelling of 228.77 ± 9.84% and release of 30.58 ± 3.25% (P< 0.05). Release kinetics followed Higuchi model with Fickian diffusion, thereby indicating a swelling-dependent release. Altering the design parameters also showed significant changes in pore size and porosity, thereby supporting the swelling and drug delivery behavior from scaffolds.

Details

Language :
English
ISSN :
25857290 and 13369075
Issue :
Preprints
Database :
Supplemental Index
Journal :
Chemical Papers
Publication Type :
Periodical
Accession number :
ejs52236745
Full Text :
https://doi.org/10.1007/s11696-019-01024-0