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Sustained protein therapeutics enabled by self-healing nanocomposite hydrogels for non-invasive bone regenerationElectronic supplementary information (ESI) available. See DOI: 10.1039/c9bm01455a
- Source :
- Biomaterials Science; 2020, Vol. 8 Issue: 2 p682-693, 12p
- Publication Year :
- 2020
-
Abstract
- Bone tissue engineering based on stem cells, growth factors and bioactive scaffolds presents an appealing but challenging approach for rehabilitation of patients with bone defects. A versatile system with the capability for easy operation and precise protein delivery in specific locations is attractive for enhancing bone regeneration. Here, we develop a non-invasive delivery system based on injectable and self-healing nanocomposite hydrogels for sustained protein release, which has the potential to improve the current orthopedic strategy. Specifically, LAPONITE® (LAP) nanoplatelets are able to accelerate the gelation process through hydrogen bonds with polysaccharide matrices, endowing hydrogels with superior mechanical and rheological behaviors, along with better injectability and self-healing ability. Attractively, the strong static binding between LAP nanoplatelets and bone morphogenetic protein-2 (BMP-2) can form stable LAP@BMP-2 complexes. The results indicate that the complexes effectively preserve the intrinsic bioactivity of BMP-2 and prolong the release period for more than four weeks. Moreover, hydrogels incorporating with the LAP@BMP-2 complexes synergistically boost cell spreading, proliferation activity and osteogenesis, both in vitroand in vivo, compared with LAP or BMP-2 alone. Overall, this study proposes a valid platform for protein therapeutics and non-invasive bone repair.
Details
- Language :
- English
- ISSN :
- 20474830 and 20474849
- Volume :
- 8
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Biomaterials Science
- Publication Type :
- Periodical
- Accession number :
- ejs52143083
- Full Text :
- https://doi.org/10.1039/c9bm01455a