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Sister chromatid exchange induced by chromium compounds in human lymphocytes
- Source :
- International Archives of Occupational and Environmental Health; 19981116, Vol. 71 Issue: 8 p550-553, 4p
- Publication Year :
- 1998
-
Abstract
- Abstract: The objective of this study was to study was to compare chromium (Cr), nickel-chromium (Ni-Cr), and control groups for sister chromatid exchange (SCE) in lymphocytes to obtain an understanding of the mutagenic effect of Cr(VI) in humans. Subjects totaled 91 persons from the 3 groups, including 14 Cr and 34 Ni-Cr electroplating workers and 43 control group members. Results showed that blood and urine Cr concentrations were highest among Cr workers (11.39 μg/l, 14.7 μg/g creatinine), next highest among Ni-Cr workers (5.28 μg/l, 6.2 μg/g creatinine), and lowest among the control group (2.36 μg/l, NA). After adjustment for smoking habits, SCE/cell values were 10.6, 9.4, and 8.3 for Cr workers, Ni-Cr workers, and controls, respectively. A synergetic effect was shown on HFC (high-frequency cells) percentages for Cr workers who also smoked. Odds ratios were 31.78 and 3.66 that Cr and Ni-Cr workers would have higher HFC percentages than the control group, respectively. The authors conclude that SCE in lymphocytes is useful for evaluation of the biological effects of environmental mutagens.
Details
- Language :
- English
- ISSN :
- 03400131 and 14321246
- Volume :
- 71
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- International Archives of Occupational and Environmental Health
- Publication Type :
- Periodical
- Accession number :
- ejs520948
- Full Text :
- https://doi.org/10.1007/s004200050322