Pediatric optic neuritis and anti MOG antibodies: a cohort of Italian patients

•Optic disc edema at onset is suggestive for MOG positive optic neuritis.•Increased retinal nerve fiber layer at onset is suggestive for MOG positive optic neuritis.•Visual acuity impairment is similar at onset in MOG positive and seronegative optic neuritis.•MOG positive patients show better outcome.•Multiple sclerosis is frequent in seronegative optic neuritis, but is exceptionally rare in MOG positive optic neuritis.