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Magnetically Guided Theranostics: Optimizing Magnetic Resonance Imaging with Sandwich-Like Kaolinite-Based Iron/Platinum Nanoparticles for Magnetic Fluid Hyperthermia and Chemotherapy
- Source :
- Chemistry of Materials; January 2020, Vol. 32 Issue: 2 p697-708, 12p
- Publication Year :
- 2020
-
Abstract
- Hepatocellular carcinoma (HCC) is a common type of liver cancer that can be diagnosed by magnetic resonance imaging (MRI). If diagnosing HCC by basic MRI is difficult, then doctors use T1-weighted or T2-weighted imaging with a contrast agent that has long-term retention in the liver, such as Fe3O4or FePt, to aid in MRI diagnosis. One challenging goal of cancer prevention is developing a method that can further treat or inhibit HCC cells at the time of diagnosis. Functionalized porous kaolinite can serve not only as a drug delivery system for treating cancer cells but also as a scaffold to carry FePt nanoparticles (FePt NPs) and drugs such as doxorubicin (Dox). FePt NPs combined with kaolinite modified with cetyltrimethylammonium bromide (CTAB) can form FePt@Kao nanocomposites. Multifunctional FePt@Kao can serve as a magnetic fluid hyperthermia (MFH) agent that can also be used to simultaneously visualize and treat HCC cancer cells. After being loaded with the chemotherapeutic drug Dox, FePt@Kao-Dox can provide both MFH treatment and chemotherapy. From the systematic analysis results, we demonstrated that this functionalized FePt@Kao-Dox nanocomposite can be successfully used as a platform to integrate MRI, magnetically guided targeting, and therapeutic treatment into a multifunctional drug delivery system.
Details
- Language :
- English
- ISSN :
- 08974756
- Volume :
- 32
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Chemistry of Materials
- Publication Type :
- Periodical
- Accession number :
- ejs51840539
- Full Text :
- https://doi.org/10.1021/acs.chemmater.9b03552