Back to Search Start Over

Telomere length and associated factors in older adults with hypertension

Authors :
Liu, Pan
Zhang, Yaxin
Ma, Lina
Source :
Journal of International Medical Research; November 2019, Vol. 47 Issue: 11 p5465-5474, 10p
Publication Year :
2019

Abstract

Telomeres and telomerase play important roles in the occurrence and development of hypertension. This review was performed to clarify the factors that influence telomere length and telomerase activity in older patients and elucidate the association of these factors with hypertension. A PubMed search and critical review of studies assessing the risk factors underlying the association of hypertension with telomere length and telomerase activity was performed. Telomere length and telomerase activity were found to be associated with hypertension. The factors that influence telomere length and telomerase activity in older patients with hypertension include genetics, demographics, social and environmental factors, chronic disease, psychological factors, and antihypertensive drug treatment. A better understanding of the molecular mechanisms underlying the association of hypertension with telomere length and telomerase activity may help to reduce the incidence of hypertension.

Details

Language :
English
ISSN :
03000605 and 14732300
Volume :
47
Issue :
11
Database :
Supplemental Index
Journal :
Journal of International Medical Research
Publication Type :
Periodical
Accession number :
ejs51557914
Full Text :
https://doi.org/10.1177/0300060519882570