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African ST173 Cryptococcus deuterogattiistrains are commonly less susceptible to fluconazole: An unclear mechanism of resistance
- Source :
- Journal of Global Antimicrobial Resistance; June 2020, Vol. 21 Issue: 1 p262-269, 8p
- Publication Year :
- 2020
-
Abstract
- •All Ivorian Cryptococcus deuterogattiiisolates were identified as ST173 by MLST.•64.3% (18/28) of isolates had a fluconazole (FCZ) MIC of ≥16μg/mL.•FCZ exposure increased AFR1mRNA expression, especially in isolates with high FCZ MICs.•Resistance mechanisms described in Cryptococcus neoformanswere not involved in C. deuterogattiiST173 isolates.
Details
- Language :
- English
- ISSN :
- 22137165
- Volume :
- 21
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Global Antimicrobial Resistance
- Publication Type :
- Periodical
- Accession number :
- ejs51496719
- Full Text :
- https://doi.org/10.1016/j.jgar.2019.10.017