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The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial

Authors :
Burns, Daniel K.
Chiang, Carl
Welsh-Bohmer, Kathleen A.
Brannan, Stephen K.
Culp, Meredith
O'Neil, Janet
Runyan, Grant
Harrigan, Patrick
Plassman, Brenda L.
Lutz, Michael
Lai, Eric
Haneline, Stephen
Yarnall, David
Yarbrough, Deborah
Metz, Craig
Ponduru, Sridevi
Sundseth, Scott
Saunders, Ann M.
Dubois, Bruno
Cummings, Jeffrey
Doody, Rachelle
Lyketsos, Constantine
Reiman, Eric
Welsh-Bohmer, Kathleen A.
Welsh-Bohmer, Kathleen A.
Sano, Mary
Schneider, Lon
Craft, Suzanne
Espeland, Mark
Monsch, Andreas
Source :
Alzheimer's & Dementia: Translational Research & Clinical Interventions; January 2019, Vol. 5 Issue: 1 p661-670, 10p
Publication Year :
2019

Abstract

Alzheimer's disease (AD) is a continuum with neuropathologies manifesting years before clinical symptoms; thus, AD research is attempting to identify more disease-modifying approaches to test treatments administered before full disease expression. Designing such trials in cognitively normal elderly individuals poses unique challenges.

Details

Language :
English
ISSN :
23528737
Volume :
5
Issue :
1
Database :
Supplemental Index
Journal :
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Publication Type :
Periodical
Accession number :
ejs51416423
Full Text :
https://doi.org/10.1016/j.trci.2019.09.010